Difference and Similarities of Lantus and Levemir

Lantus and Levemir are two types of long-acting insulin which is injectable and used in the treatment of diabetes. They can be used by both children and adults. Human insulin is made up of amino acid chains, A and B.

Insulin is produced naturally in the body by the pancreas. It converts tissues in the bloodstream into energy which we use daily. With no insulin in the torso, the sugar levels will become dangerously high and out of balance. Hence, diabetes takes birth.

diabetesDiabetes is a condition where the pancreas uses little or no insulin at all. Patients with diabetes type 1 and type 2 must use insulin to maintain body sugar. Both are insulin analogues, where the insulin molecules are analogous to human insulin. But when recombined with slight differences it reduces their absorption.

How are Lantus and Levemir made?

Lantus: Vat of E bacteria produces Glargine. It’s then purified and added to a watery solution containing zinc and glucose and hydrochloric acid for a little bit of acidity. The pH levels are brought down to 4. Once it’s down, glargine completely dissolves in water hence the vial is absolutely clear. Once it’s injected, the acidic solution is neutralized by the body.

Levemir: This is made with insulin detemir. It’s created with a recombination of DNA technology like Lantus but made with baker’s yeast and not E.coil. It contains some additional chemicals as used in Lantus. Insulin detemir differs from human insulin where one amino acid has been omitted from B chain. One fatty acid has been attached instead.

Similarities between Lantus and Levemir

Both, Lantus and Levemir are meant for daily diabetes management. Both are not meant for treating high sugar or ketoacidosis. Levemir resulted in less weight gain, whereas Lantus had fewer skin reactions and required lower daily dose. Both can lower the blood sugar slowly but are long lasting.

However, as per a study, there was no significant difference in the safety and effectiveness of the type 2 disease between the two. They both take 24 hours’ time to be absorbed.

Differences between Lantus and Levemir

Levemir is long-acting insulin providing all-day sugar control. It can cause low blood sugar, so understand the symptoms are and always have a source of sugar close by. Lantus is Insulin Glargine, which is a long-acting insulin that provides all-day sugar control. This can also cause low blood sugar.

In Glargine, amino acid has been switched off and 2 extras are added at the B chain. Hence, it’s made soluble in the pH, but less soluble at the neutral pH which is found in the body.


Levemir can be taken in one or two doses in a day. If taken once a day, it’s recommended that you take it during dinner or before sleeping. If taken twice, keep a gap of 12 hours. Lantus is taken once a day. The timings are based on the glucose-based target. It’s better to take the physician’s advice on this one.

The insulin intake will depend on the type of disease that you have. The solution for the injection is 100 units/ml. The solution is colourless and clear. Both Lantus and Levemir should not be used with a pump. This could be life threatening for the patient as it results in severe low blood sugar.

Injections should never be taken in the vein or muscle, but under the skin. It’s important to keep rotating the places from the last dosage. This is avoiding fatty tissue build up. Dosage adjustments can be necessary.